[R] how to calculate multiple meta p values

[Ana Marija]

this is the function I was referring to:
https://www.rdocumentation.org/packages/metap/versions/1.1/topics/sumz

On Fri, Oct 25, 2019 at 6:31 PM Ana Marija <sokovic.anamarija using gmail.com> wrote:
>
> Hello,
>
> I would like to use this package metap
> to calculate multiple o values
>
> I have my data frame with 3 p values
> > head(tt)
>           RS            G           E          B
> 1: rs2089177   0.9986   0.7153   0.604716
> 2: rs4360974   0.9738   0.7838   0.430228
> 3: rs6502526   0.9744   0.7839   0.429160
> 4: rs8069906   0.7184   0.4918   0.521452
> 5: rs9905280   0.7205   0.4861   0.465758
> 6: rs4313843   0.9804   0.8522   0.474313
>
> and data frame with corresponding weights for each of the p values
> from the tt data frame
>
> > head(df)
>        wg       we             wb                RS
> 1 40.6325 35.39774 580.6436 rs2089177
> 2 40.6325 35.39774 580.6436 rs4360974
> 3 40.6325 35.39774 580.6436 rs6502526
> 4 40.6325 35.39774 580.6436 rs8069906
> 5 40.6325 35.39774 580.6436 rs9905280
> 6 40.6325 35.39774 580.6436 rs4313843
>
> RS column is the same in df and tt
>
> How to use this sunz() function to create a new data frame which would
> look the same as tt only it would have additional column, say named
> "META" which has calculated meta p values for each row
>
> This i s example of how much would be p value in the first row:
>
> > sumz(c(0.9986,0.7153,0.604716), weights = c(40.6325,35.39774,580.6436), na.action = na.fail)
> p =  0.6940048
>
> Thanks
> Ana