[R] How to fit a Hill model using braidrm package?

[Luigi Marongiu]

Thank you but I am getting several error installing drc on Fedora...

On Wed, Sep 24, 2025 at 1:47 PM peter dalgaard <pdalgd using gmail.com> wrote:
>
> They're in basicdrm, not braidrm...
>
> -pd
>
> > On 24 Sep 2025, at 11:52 , Luigi Marongiu <marongiu.luigi using gmail.com> wrote:
> >
> > Hello,
> > I have a set of data coming from a dissociation experiment
> > (protein/ligand). Since the data is required to calculate the constant
> > of dissociation (Kd) of this pair, I am looking for a way of fitting a
> > Hill function to the data.
> > I have seen that the package braidrm
> > (https://cran.r-project.org/web/packages/braidrm/index.html) provides
> > this function, but when I launch the function `evalHillEqn`,
> > `findBestHill` and so forth I get the error of function not found.
> > Yet, the package is given as properly installed by the system.
> > How can I run this package?
> > Is there an alternative way to fit a Hill function to these data?
> > Thank you
> >
> > ```
> > df = data.frame(Response =    c(890.72,    895.46,    895.63,
> > 894.72,    895.49,    893.59,
> >                892.53,    895.06,    897.21,    889.27,    876.05,
> > 857.96,    862.02,    858.36,
> >                890.94,    890.8,    887.22,    888.91,    890.83,
> > 889.92,    891.76,    890.32,
> >                886.35,    878.11,    866.57,    859.04,    863.64,
> > 880.16,    884.15,    879.57,
> >                878.89,    882.27,    881.59,    880.98,    881.45,
> > 876.19,    868.32,    859.16,
> >                850.53,    853.21,    859.34,    859.73,    861.19),
> >                Dose =    c(0.0000000015,    0.000000003,
> > 0.000000006,    0.000000012,
> >                       0.000000024,    0.000000048,    0.000000095,
> > 0.00000018,
> >                       0.00000038,    0.00000078,    0.0000015,
> > 0.000013,    0.000025,
> >                       0.00005,    0.0000000015,    0.000000003,
> > 0.000000006,
> >                       0.000000012,    0.000000024,    0.000000048,
> > 0.000000095,
> >                       0.00000018,    0.00000038,    0.00000078,
> > 0.0000015,    0.000025,
> >                       0.00005,    0.0000000015,    0.000000003,
> > 0.000000006,
> >                       0.000000012,    0.000000024,    0.000000048,
> > 0.000000095,
> >                       0.00000018,    0.00000038,    0.00000078,
> > 0.0000015,    0.000003,
> >                       0.000006,    0.000013,    0.000025,    0.00005)
> > )
> > plot(Response~log10(Dose), df)
> > library(braidrm)
> > evalHillEqn(Response~Dose, df)
> > findBestHill(Response~Dose, df)
> > ```
> >
> > ______________________________________________
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>
> --
> Peter Dalgaard, Professor,
> Center for Statistics, Copenhagen Business School
> Solbjerg Plads 3, 2000 Frederiksberg, Denmark
> Phone: (+45)38153501
> Office: A 4.23
> Email: pd.mes using cbs.dk  Priv: PDalgd using gmail.com
>


-- 
Best regards,
Luigi