[R] frailtypack

Terry Therneau therneau at mayo.edu
Wed Oct 9 16:36:06 CEST 2013

I can't comment on frailtypack issues, but would like to mention that coxme will handle 
nested models, contrary to the statement below that "frailtypack is perhaps the only .... 
for nested survival data".
To reprise the original post's model

    cgd.nfm <- coxme(Surv(Tstart, Tstop, Status) ~ Treatment + (1 | Center/ID), data=cgd.ag)

And a note to the poster-- you should reprise the original message to which you are 

Terry Therneau

On 10/09/2013 05:00 AM, r-help-request at r-project.org wrote:
> Hello,
> I am encountering very similar problems with frailtypack (only, it seems, 3
> years later).  I would be incredibly grateful if you would be willing to
> share any solutions you happened upon for the problem you mention. I have a
> datafile that is even longer than yours (over 15000 events). Events follow a
> two-level nesting structure. When I attempt to run the nested survival model
> in frailtypack the program either stops running entirely or produces an
> error message. I have contacted the frailtypack maintainer but have not yet
> received a response.  It seems that frailtypack is perhaps the only
> widely-available platform for the analysis of nested survival data, so the
> seeming bugginess of this program is troubling.  Please let me know if you
> ended up coming up with a solution to your problem or, alternatively,
> another program able to run the nested analysis. Thank you so much!

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