[R] scientific (statistical) foundation for Y-RANDOMIZATION in regression analysis

[tauQSAR]

Hello,
I'm also working on a QSAR validation, and would like to confirm that my
multiple least squares regression based on only 4 x-variables out of a pool
of 300 x-variables is significant. I want to apply the y-randomization or
y-scrambling permutation protocol using R, but I have not been able to 
find any examples that are similar to my problem.
Could someone clarify whether this type of validation protocol could be
done with the R 'boostrap' function, or 'onetPermutation' or 'sample'?
I'm not a statistician and I'm having a hard time deciphering the code
and explanations in the manual, so help would be greatly appreciated!!!!
Thanks!!


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