[R] Experimental Design

Isaac Neuhaus isaac.neuhaus at bms.com
Thu May 22 14:27:51 CEST 2003

I don't know if this is the best place to post this question but I will 
try anyway. I have two experiements for which I use one-way 
matched-randomized ANOVA for the analysis and I would like to compare 
different treatments in the two experiments. The only common group in 
the two experiments are the controls. Is there any  ANOVA design that 
allows me  to  make this comparison taking into consideration the 
confounding effect? Any help would be greatly appreciated.


A representation of the experiments follows:

Experiment 1
           Control1     Treat1      Treat2
Blk1          s1          s2          s3
Blk2          s4          s5          s6
Blk3          s7          s8          s9

Experiment 2
           Control2     Treat3      Treat4
Blk1          s1a          s2a          s3a
Blk2          s4a          s5a          s6a
Blk3          s7a          s8a          s9a

Control1 and Control2 I are the same control cell line. I would like to 
compare Treat1 to Treat3 and Treat 4 and also I would like to compare 
Treat2 to Treat3 and Treat4. The fact that those experiments are done in 
two different blocks will confound the interpretation. Can I use the 
common control group to build a model? Should I include one of the 
treatments in future experiments to test my model?

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