[R] quinModel S != R

Dieter Menne dieter.menne at menne-biomed.de
Sun Feb 4 21:20:38 CET 2001

Dear friends of nlme,

Running quinModel (Pinheiro/Bates page 380) on R (current release, windows)

Nonlinear mixed-effects model fit by maximum likelihood
  Model: conc ~ quinModel(Subject, time, conc, dose, interval, lV, lKa,
  Data: Quinidine
  Log-likelihood: -497
  Fixed: lV + lKa + lCl ~ 1
    lV    lKa    lCl
 5.382 -0.273  2.470

Random effects:
 Formula: list(lV ~ 1, lCl ~ 1)
 Level: Subject
 Structure: Diagonal
              lV   lCl Residual
StdDev: 4.43e-12 0.321     0.76

lV is confusing, since the book examples says it should be 0.31173.

Other question: is the source of nlme_one_comp_open (or similar) available?
I would like to learn how to do these models in c, but could not find the
code. (To avoid RTFM: I know about r-ext.pdf, but a special modelxXX example
would make life easier).


Dr. Dieter Menne
Biomed Software
72074 Tübingen
Tel (49) (7071) 52176
FAX (49) (7071) 55 10 46
dieter.menne at menne-biomed.de

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