[BioC] Count outlier detection and endogenous gene normalization

[FeiYian Yoong [guest]]

Hi there, 

I am wondering:

i) When do you perform count outlier detection step? Do you do it after filtering/differential expression analysis OR before both steps?

ii) It doesn't seem like DESeq2 take into account normalizing samples against endogenous or consistently expressed genes for differential expression analysis. Do you recommend that?


Thank you in advance!!

Yoong

 -- output of sessionInfo(): 

NA

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