[BioC] On empirical Bayes of edgeR

[Bin Zhuo [guest]]

Dear all,

Recently I'm reading the  paper "Moderated statistical tests for assessing differences in tag abundance"(http://bioinformatics.oxfordjournals.org/content/23/21/2881.full.pdf+html).

In part 3.2 where the estimation algorithm was stated, I have trouble understanding ALGORITHM STEP (3). My question was, How does the equation in STEP (3) relate to that in equation (4), the one right above this paragraph?  I'm confused especially by the denominator( I_g(1+I_g\tau_0^2) )in the bracket.  Is there any reference about on this particular point?

Thanks,
Bin Zhuo

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