[BioC] significance of correlation genes/miRNAs expression

[Paul Geeleher]

One (of many) possible solutions would be to summarize the expression
of each set of miRNA target genes by their "RE-score". See these
papers:

http://genomebiology.com/2009/10/9/R90
http://www.biomedcentral.com/1471-2164/13/383

Then, once you have an RE-score and an expression level vector for
each miRNA, use the cor.test() function in R to test the significance
of the correlation.

Paul.

On Fri, Jan 4, 2013 at 3:17 AM, Seb <seba.bat at gmail.com> wrote:
> hope this question is in topic.
>
> I have expression values from a miRNA microarray and a gene expression
> microarray in the same cel line,  some genes show opposite expression
> pattern with the miRNAs that supposedly regulate them (so that's
> good)...how can i evaluate the significance of that inverse
> correlation?
> there is any package that i could use to "evaluates" those things?
>
> thanks
>
> Seb
>
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-- 
Dr. Paul Geeleher
School of Mathematics, Statistics and Applied Mathematics
National University of Ireland
Galway
Ireland
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