[BioC] statistical test for time course data

[Richard Friedman]

Gordon,

	Thank you. The example is clear.
Is there a minimum # of time points for which this
works? Or to phrase it somewhat differently, what is
the relationship between the n (the degree of the spline)
and t, the minimum number of time points necessary to 
parameterize the spline?

	Also, how do I know how many parameters is in the
model and which coefficients to use?
	Can you please point me at a reference which treats this
kind of model?

Thanks and best wishes,
Rich
 

On Feb 4, 2013, at 10:02 PM, Gordon K Smyth wrote:

> Dear Rich,
> 
> I have added a time course example using splines to the limma User's Guide, see page 48:
> 
> http://bioconductor.org/packages/2.12/bioc/vignettes/limma/inst/doc/usersguide.pdf
> 
> Best wishes
> Gordon
> 
> ------------------ original message ------------------
> [BioC] statistical test for time course data
> Richard Friedman friedman at cancercenter.columbia.edu
> Sun Feb 3 20:18:03 CET 2013
> 
> Dear Gordon,
> 
> 	Thank you very much for the clarification. Now that I think of it, the one-against all is straightforward. However, If there are any worked examples you could point me towards for polynomial and spline modeling of the time series I would greatly appreciate it. I am especially interested in testing the hypothesis that the temporal behavior of 2 treatments are different.
> 
> Best wishes,
> Rich
> 
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