[BioC] DEseq and FDR correction

[Wolfgang Huber]

Jun/28/12 7:41 PM, Oren Schaedel scripsit::
> Hello everyone,
> I'm new to the bioconducter list, and I have a question about DEseq:
> Is it necessary to perform the FDR correction even though the variance is
> estimated by the hierarchical model? I ask this because the values of
> neighboring genes (hypothesis for the FDR) are used for the variance
> estimation. Do we need to take into account these values again?
>
>
> Thanks for your help
>

Dear Oren

multiple testing adjustment is needed after an analysis with DESeq just 
as with any other gene-by-gene testing method.

Best wishes
	Wolfgang

Wolfgang Huber
EMBL
http://www.embl.de/research/units/genome_biology/huber