[BioC] annotation in Ensembl using biomart

[Wolfgang Huber]

Dear Jason

a quick look at the HGNC website (http://www.genenames.org) will tell 
you that CDC2L1 is the previous name for CDK11B (the currently approved 
gene symbol) and similarly CDC2L2 for CDK11A and furthermore that 
Ensembl as well as the UCSC genome browser in the meanwhile map them to 
the same place in the reference genome and consider them isoforms of the 
same gene:
http://www.genenames.org/data/hgnc_data.php?hgnc_id=1729
http://www.genenames.org/data/hgnc_data.php?hgnc_id=1730

OTOH, Entrez and UniProt consider them as separate genes ("Duplicated 
gene. CDK11A and CDK11B encode almost identical protein kinases of 110 
kDa that ..."): http://www.uniprot.org/uniprot/Q9UQ88

Biology, and the history of biological discovery, can be messy...
Other people might have more insight, but I bet it is a long story :)

	Wolfgang


Jason Lu scripsit 11/03/10 17:06:
> Hi all,
> 
> I wonder whether I could help from this list. Sorry if this is a
> duplicate question.
> 
> I get confused with the following mapping (by using the BioMart
> website). They share the same ENSG. My purpose is to match ENSG to a
> gene symbol.
> Do you have any suggestion which one I should use?
> Thanks,
> 
> 
> Ensembl Gene ID Ensembl Transcript ID HGNC symbol HGNC curated gene name
> ENSG00000008128 ENST00000401097 CDK11B CDC2L2
> ENSG00000008128 ENST00000401097 CDK11A CDC2L2
> ENSG00000008128 ENST00000401097 CDK11B CDC2L1
> ENSG00000008128 ENST00000401097 CDK11A CDC2L1
> ENSG00000008128 ENST00000341832 CDK11B CDC2L2
> ENSG00000008128 ENST00000341832 CDK11A CDC2L2
> ENSG00000008128 ENST00000341832 CDK11B CDC2L1
> ENSG00000008128 ENST00000341832 CDK11A CDC2L1
> ENSG00000008128 ENST00000407249 CDK11B CDC2L2
> ENSG00000008128 ENST00000407249 CDK11A CDC2L2
> 
> Jason
> 
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-- 

Best wishes
      Wolfgang


--
Wolfgang Huber
EMBL
http://www.embl.de/research/units/genome_biology/huber/contact