[BioC] Normalization of miRNA arrays

[Denise Mauldin]

Hello all,

I'm working on some microRNA arrays that were not run without spike in 
controls, but do have U6 and SNORD controls (from the samples).  They were 
run EXP vs STD with dye swaps.  I've tried using a global loess 
normalization, but it makes a few of the arrays come out looking 
strangely.  Anyone have any other suggestions on normalization methods 
that might be appropriate for this data set?

Thanks,
Denise